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166 28 Prague 6 – Dejvice
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Copyright: UCT Prague 2015
Information provided by the Department of Organic Chemistry. Technical support by the Computing Centre.
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All publications of our authors (since 2015): here
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| k Phonebook of the Department | |||
Professors: |
|||
|
Prof. Radek Cibulka e +420 22044 4182 d A 278c |
Head of Department | www | ResearcherID |
|
Prof. Pavel Lhoták e +420 22044 5055 d A 249 |
www | ||
|
Prof. Jaroslav Kvíčala e +420 22044 4240 d A 278d |
www | ||
|
Prof. Jiří Svoboda e +420 22044 3688 d A 278e |
www | ||
Associate Professors: |
|||
|
Assoc. Prof. Jan Budka e +420 22044 4284 d A 251 |
DOC web editor | www | |
|
Assoc. Prof. Jana Hodačová e +420 22044 4173 d A 270 |
www | ||
|
Assoc. Prof. Michal Kohout e +420 22044 5012 d A 258 |
www | ||
|
Assoc. Prof. Igor Linhart e +420 22044 4165 d A 266 |
www | ||
|
Assoc. Prof. Tomáš Tobrman e +420 22044 4245 d A 271 |
RIT | www | |
Assistant Professors: |
|||
|
Dr. Michal Himl e +420 22044 4165 d A 266 |
www | ||
|
Dr. Roman Holakovský e +420 22044 4279 d A 255 |
www | ||
|
Dr. Petr Kovaříček e +420 22044 2040 d B3 207 |
www | ||
|
Dr. Václav Kozmík e +420 22044 4118 d A 308 |
www | ||
|
Dr. Martin Krupička e +420 220 444 173 |
www | ||
|
Dr. Ondřej Kundrát e +420 22044 4280 d A 253 |
www | ResearcherID | |
|
Dr. Petra Ménová e +420 22044 3686 d A 268 |
www | ||
|
Dr. Pavla Perlíková e +420 22044 2039 d B3 206 |
www | ||
|
Dr. Markéta Rybáčková e +420 22044 4242 d A 259 |
Secretary of Department |
www | |
|
Dr. Eva Svobodová e +420 22044 4249 d A 260 |
www | ||
Technicians: |
|||
|
Květa Bártová e +420 22044 3686 d A 268 |
|||
|
Ivana Bocková, MSc. e +420 22044 4280 d A 250 |
|||
| Michaela Kadlecová
e +420 22044 4276 d A 262 b Michaela.Kadlecova@vscht.cz |
|||
|
Martina Kovandová e +420 22044 4279 d A 255 |
|||
|
Vladimír Kuneš e +420 22044 4277 d A L06 |
|||
|
Jana Netušilová e +420 22044 4164 d A 278a |
Administrative Support of Department | ||
|
Markéta Slabochová, MSc. e +420 22044 4059 d A 308 |
Economist of Department | ||
|
Helena Štenglová e +420 22044 4278 d A 257 |
|||
|
Ing. David Tetour e +420 22044 4173 d A270 |
|||
|
Marta Tokárová e +420 220 444 245 d A 271 |
|||
Essential Information for Current Students
Bachelor Students
Master Students
PhD Students
Lectures delivered by members of the Department
- Toxicology and ecology
- Organic chemistry I, II and III
- Structural analysis
- Reactivity of organic compounds
- Molecular design
- Organic synthesis I and II
- Quantum organic chemistry
- Farmacochemistry
- Organic stereochemistry
- Organometallic chemistry
- Organic chemistry of selected elements
DATA
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[obsah] => Selected publications (2005-2019)
Linhart, I.:
Chemická legislativa pohledem laboratorního chemika.
Chem. Listy 2019, 113, 140 – 148.
Mraz, J.; Hanzlikova, I.; Duskova, S.; Dabrowska, L.; Linhart, I.; Hejl, K.:
N-(2-Hydroxyethyl)-L-valyl-L-leucine in rat urine as a hydrolytic cleavage product of ethylene oxide adduct with globin
Archives of Toxicology 2019 93, 603 – 613 DOI:10.1007/s00204-019-02388-8
Mraz, J.; Hanzlikova, I.; Duskova, S.; Tvrdikova, M.; Chrastecka, H.; Vajtrova, R.; Linhart, I.:
Determination of N-(2-hydroxyethyl)valine in globin of ethylene-exposed workers using total acidic hydrolysis and HPLC-ESI-MS2
Toxicology Letters 2018, 298, 76-80 DOI:10.1016/j.toxlet.2018.06.1212
Zidkova, M.; Linhart, I.; Balikova, M.; Himl, M.; Dvorackova, V.; Lhotkova, E.; Palenicek, T.:
Identification of three new phase II metabolites of a designer drug methylone formed in rats by N-demethylation followed by conjugation with dicarboxylic acids
Xenobiotica 2018, 48, 618-625 DOI: 10.1080/00498254.2017.1349964
Linhart, I.; Hanzlikova, I.; Mraz, J.; Duskova, S.:
S-(3-Aminobenzanthron-2-yl)cysteine in the globin of rats as a novel type of adduct and possible biomarker of exposure to 3-nitrobenzanthrone, a potent environmental carcinogen
Archives of Toxicology 2017, 91, 3317-3325 DOI:10.1007/s00204-017-1943-8
Zidkova, M.; Linhart, I.; Balikova, M.; Himl, M.; Vana, L.; Vetyska, M.; Palenicek, T.; Lhotkova, E.; Dusek, M.:
Study on metabolism of 5,6-methylenedioxy-2-aminoindane (MDAI) in rats: identification of urinary metabolites
Xenobiotica 2017, 47, 505-514 DOI:10.1080/00498254.2016.1199919
Mraz, J.; Hanzlikova, I.; Duskova, S.; Dabrowska, L.; Chrastecka, H.; Vajtrova, R.; Linhart, I.:
Biological fate of styrene oxide adducts with globin: Elimination of cleavage products in the rat urine
Toxicology Letters 2016, 261, 26-31 DOI:10.1016/j.toxlet.2016.08.022
Navratil, R.; Tarabek, J.; Linhart, I.; Martinů, T.:
Radical and Nitrenoid Reactivity of 3-Halo-3-phenyldiazirines
Org. Lett. 2016, 18, 3734–3737 DOI:10.1021/acs.orglett.6b01753
J. Mraz, I. Hanzlikova, A. Moulisova, S. Duskova, K. Hejl, A. Bednarova, L. Dabrowska, I. Linhart:
Hydrolytic cleavage products of globin adducts in urine as possible biomarkers of cumulative dose: Proof of concept using styrene oxide as a model adduct-forming compound
Chemical Research in Toxicology 29, 676-686 (2016)
I. Linhart, M. Himl, M. Zidkova, M. Balikova, E. Lhotakova, T. Palenicek:
Metabolic profile of mephedrone: Identification of normephedrone conjugates with dicarboxylic acids as a new type of xenobiotic phase II metabolites
Toxicology Letters 240, 114-121 (2016)
A. Kralík, I. Linhart, L. Váňa, A. Moulisová:
Identification of new DNA adducts of phenylnitrenium
Chemical Research in Toxicology 28, 1317-1325 (2015)
A. Moulisová, I. Linhart:
Preparation of cysteine adducts by regioselective ring-opening reactions of phenyloxirane
Heterocyclic Commun. 21, 61-65 (2015)
L. Váňa, L. Vrzal, H. Dvořáková, M. Himl a I. Linhart:
Direct arylation of adenine by fluoro- and chloronitrobenzenes. Effect of microwaves.
Synth. Commun. 44, 788-799 (2014)
P. Mikeš, V. Šístek, J. Krouželka, A. Králík, E. Frantík, J. Mráz a I. Linhart:
3-(3,4-Dihydroxyphenyl)adenine, a urinary DNA adduct formed in mice exposed to high concentrations of benzene.
Appl. Toxicol. 33, 516-520 (2013)
I. Linhart:
Toxikologie. Interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky.
ISBN: 978-80-7080-806-1, VŠCHT Praha, 2012
K. Míčová, I. Linhart:
Reactions of benzene oxide, a reactive metabolite of benzene, with model nucleophiles and DNA.
Xenobiotica 42, 1028-1037 (2012)
I. Linhart, J. Mráz, I. Hanzlíková, A. Šilhánková, E. Frantík, M. Himl:
Carcinogenic 3-nitro-benzanthrone but not 2-nitrobenzanthrone is metabolised to an unusual mercapturic acid in rats.
Toxicol. Lett. 208, 246-253 (2012)
I. Linhart, J. Mráz, L. Danbrowská, M. Mališ, J. Krouželka, M. Kořínek:
Viniylmercapturic acids in human urine as biomarkers of styrene ring oxidation.
Toxicol. Lett. 213, 260-265 (2012)
I. Linhart, P. Mikeš, A. Králík, J. Mráz, E. Frantík:
Metabolism of N2-(4-hydroxyphenyl)guanine, a DNA adduct formed from p-benzoquinone, in rat.
Toxicol. Lett. 205, 273-278 (2011)
I. Linhart, P. Mikeš, E. Frantík, J Mráz:
DNA Adducts Formed from p-Benzoquinone, an Electrophilic Metabolite of Benzene, Are Extensively Metabolized in Vivo.
Chem. Res. Toxicol. 24, 383-391 (2011)
P. Mikeš, M. Kořínek, I. Linhart, J. Krouželka, L. Dabrowská, V. Stránský, J. Mráz:
Urinary N3 adenine DNA adducts in humans occupationally exposed to styrene.
Toxicol. Lett. 197, 183-187 (2010)
I. Linhart, J. Mráz, J. Scharff, J. Krouželka, S. Dušková, H. Nohová, L. Vodičková:
New Urinary Metabolites Formed from Ring-Oxidized Metabolic Intermediates of Styrene
Chem. Res. Toxicol., 23, 251-257 (2010)
J. Krouželka, I. Linhart:
Copper-mediated N-arylation in the synthesis of aryladenines
Heterocycles, 78, 1205-1226 (2009)
P. Mikeš, M. Kořínek, I. Linhart, J. Krouželka, E. Frantík, L. Vodičková, N. Neufussová:
Excretion of urinary N7 guanine and N3 adenine DNA adducts in mice after inhalation of styrene
Toxicol. Lett., 184, 33-37 (2009)
J. Krouželka, I. Linhart, T. Tobrman:
Synthesis of 3-(2-hydroxy-1-phenyl)- and 3-(2-hydroxy-2-phenylethyl)adenine, DNA adducts derived from styrene
J. Heterocycl. Chem., 45, 789-795 (2008)
Jagr, M., Mráz, J., Linhart, I., Stránský, V., Pospíšil, M.
Synthesis and characterization of styrene oxide adducts with cysteine, histidine and lysine in human globin
Chem. Res. Toxicol., 20, 1442-1452 (2007)
Gut, I., Ojima, I., Vaclavikova, R., Simek, P., Horsky, S., Linhart, I., Soucek, P., Kondrova, E., Kuznetsova, L.V.
Xenobiotica, 36, 772-792 (2006)
Vodicka, P.; Linhart, I.; Novak, J.; Koskinen, M.; Vodickova, L.; Hemminki, K.:
7-Alkylguanine adduct levels in urine, lungs and liver of mice exposed to styrene
Tox. Appl. Pharmacol., 210, 1-8 (2006)
Novák, J.; Hasník, Z.; Linhart, I.:
Syntheses of O6-alkyl- and arylguanine derivatives, nucleobase adducts derived from styrene 7,8- and 3,4-oxide
Eur. J. Org. Chem., 507-515 (2006)
Dostalek, M.; Pistovcakova, J.; Jurica, J.; Tomandl, J.; Linhart, I.; Sulcova, A.; Hadasova, E.:
Effect of St. John´s wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver
Life Sci. 78, 239-244 (2005)
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