stdClass Object ( [nazev] => Department of Organic Chemistry [adresa_url] => [api_hash] => [seo_desc] => [jazyk] => [jednojazycny] => [barva] => [indexace] => 1 [obrazek] => [ga_force] => [cookie_force] => [secureredirect] => [google_verification] => UOa3DCAUaJJ2C3MuUhI9eR1T9ZNzenZfHPQN4wupOE8 [ga_account] => UA-10822215-3 [ga_domain] => [ga4_account] => G-VKDBFLKL51 [gtm_id] => [gt_code] => [kontrola_pred] => [omezeni] => 0 [pozadi1] => [pozadi2] => [pozadi3] => [pozadi4] => [pozadi5] => [robots] => [htmlheaders] => [newurl_domain] => 'uoch.vscht.cz' [newurl_jazyk] => 'en' [newurl_akce] => '[en]' [newurl_iduzel] => [newurl_path] => 8548/6214/6521 [newurl_path_link] => Odkaz na newurlCMS [iduzel] => 6521 [platne_od] => 31.10.2023 17:15:00 [zmeneno_cas] => 31.10.2023 17:15:57.546654 [zmeneno_uzivatel_jmeno] => Jan Kříž [canonical_url] => [idvazba] => 7334 [cms_time] => 1711630692 [skupina_www] => Array ( ) [slovnik] => stdClass Object ( [logo_href] => / [logo] => [google_search] => 001523547858480163194:u-cbn29rzve [social_fb_odkaz] => https://www.facebook.com/uoch.vscht [social_tw_odkaz] => https://twitter.com/uoch_vscht [social_yt_odkaz] => [paticka_budova_a_nadpis] => BUILDING A [paticka_budova_a_popis] => Rector, Department of Communications, Department of Education, FCT Dean’s Office, Centre for Information Services [paticka_budova_b_nadpis] => BUILDING B [paticka_budova_b_popis] => Department of R&D, Dean’s Offices: FET, FFBT, FCE, Computer Centre, Department of International Relations, Bursar [paticka_budova_c_nadpis] => BUILDING C [paticka_budova_c_popis] => Crèche Zkumavka, General Practitioner, Department of Economics and Management, Department of Mathematics [paticka_budova_1_nadpis] => NATIONAL LIBRARY OF TECHNOLOGY [paticka_budova_1_popis] => [paticka_budova_2_nadpis] => CAFÉ CARBON [paticka_budova_2_popis] => [paticka_adresa] => UCT Prague
Technická 5
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Copyright: UCT Prague 2015
Information provided by the Department of Organic Chemistry. Technical support by the Computing Centre. [paticka_odkaz_mail] => mailto:kundrato@vscht.cz [social_fb_title] => Facebook of Department [social_tw_title] => Twitter of Department [social_yt_title] => [aktualizovano] => Updated [autor] => Author [paticka_mapa_alt] => [drobecky] => You are here: VŠCHT Praha – FCHT – ÚOCH [intranet_odkaz] => http://intranet.vscht.cz/ [intranet_text] => Intranet [logo_mobile_href] => / [logo_mobile] => [mobile_over_nadpis_menu] => Menu [mobile_over_nadpis_search] => Search [mobile_over_nadpis_jazyky] => Languages [mobile_over_nadpis_login] => Login [menu_home] => Homepage [zobraz_desktop_verzi] => switch to desktop version [zobraz_mobilni_verzi] => switch to mobile version [more_info] => more information [paticka_mapa_odkaz] => [nepodporovany_prohlizec] => For full access, please use different browser. [preloader] => Wait a second... [social_in_odkaz] => [den_kratky_4] => [archiv_novinek] => [novinky_servis_archiv_rok] => [novinky_kategorie_1] => [novinky_kategorie_2] => [novinky_kategorie_3] => [novinky_kategorie_4] => [novinky_kategorie_5] => [novinky_archiv_url] => [novinky_servis_nadpis] => [novinky_dalsi] => [hledani_nadpis] => hledání [hledani_nenalezeno] => Nenalezeno... [hledani_vyhledat_google] => vyhledat pomocí Google [social_li_odkaz] => ) [poduzel] => stdClass Object ( [6525] => stdClass Object ( [obsah] => [poduzel] => stdClass Object ( [6532] => stdClass Object ( [obsah] => [iduzel] => 6532 [canonical_url] => //uoch.vscht.cz [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => [html] => [css] => [js] => [autonomni] => ) ) [6530] => stdClass Object ( [obsah] => [iduzel] => 6530 [canonical_url] => //uoch.vscht.cz [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => [html] => [css] => [js] => [autonomni] => ) ) [6531] => stdClass Object ( [obsah] => [iduzel] => 6531 [canonical_url] => //uoch.vscht.cz [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => [html] => [css] => [js] => [autonomni] => ) ) ) [iduzel] => 6525 [canonical_url] => [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => [html] => [css] => [js] => [autonomni] => ) ) [6526] => stdClass Object ( [obsah] => [poduzel] => stdClass Object ( [21923] => stdClass Object ( [nazev] => Department of Organic Chemistry [seo_title] => Department of Organic Chemistry [seo_desc] => [autor] => [autor_email] => [obsah] =>New PhD topics of our department: here
All publications of our authors (since 2015): here
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k Phonebook of the Department | |||
Professors: |
|||
Prof. Radek Cibulka e +420 22044 4182 d A 278c |
Head of Department | www | ResearcherID |
Prof. Pavel Lhoták e +420 22044 5055 d A 249 |
www | ||
Prof. Jaroslav Kvíčala e +420 22044 4240 d A 278d |
www | ||
Prof. Jiří Svoboda e +420 22044 3688 d A 278e |
www | ||
Associate Professors: |
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Assoc. Prof. Jan Budka e +420 22044 4284 d A 251 |
DOC web editor | www | |
Assoc. Prof. Jana Hodačová e +420 22044 4173 d A 270 |
www | ||
Assoc. Prof. Michal Kohout e +420 22044 5012 d A 258 |
www | ||
Assoc. Prof. Igor Linhart e +420 22044 4165 d A 266 |
www | ||
Assoc. Prof. Tomáš Tobrman e +420 22044 4245 d A 271 |
RIT | www | |
Assistant Professors: |
|||
Dr. Michal Himl e +420 22044 4165 d A 266 |
www | ||
Dr. Roman Holakovský e +420 22044 4279 d A 255 |
www | ||
Dr. Petr Kovaříček e +420 22044 2040 d B3 207 |
www | ||
Dr. Václav Kozmík e +420 22044 4118 d A 308 |
www | ||
Dr. Martin Krupička e +420 220 444 173 |
www | ||
Dr. Ondřej Kundrát e +420 22044 4280 d A 253 |
www | ResearcherID | |
Dr. Petra Ménová e +420 22044 3686 d A 268 |
www | ||
Dr. Pavla Perlíková e +420 22044 2039 d B3 206 |
www | ||
Dr. Markéta Rybáčková e +420 22044 4242 d A 259 |
Secretary of Department |
www | |
Dr. Eva Svobodová e +420 22044 4249 d A 260 |
www | ||
Technicians: |
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Květa Bártová e +420 22044 3686 d A 268 |
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Ivana Bocková, MSc. e +420 22044 4280 d A 250 |
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Michaela Kadlecová
e +420 22044 4276 d A 262 b Michaela.Kadlecova@vscht.cz |
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Martina Kovandová e +420 22044 4279 d A 255 |
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Vladimír Kuneš e +420 22044 4277 d A L06 |
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Jana Netušilová e +420 22044 4164 d A 278a |
Administrative Support of Department | ||
Markéta Slabochová, MSc. e +420 22044 4059 d A 308 |
Economist of Department | ||
Helena Štenglová e +420 22044 4278 d A 257 |
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Ing. David Tetour e +420 22044 4173 d A270 |
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Marta Tokárová e +420 220 444 245 d A 271 |
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Essential Information for Current Students
Bachelor Students
Master Students
PhD Students
Lectures delivered by members of the Department
- Toxicology and ecology
- Organic chemistry I, II and III
- Structural analysis
- Reactivity of organic compounds
- Molecular design
- Organic synthesis I and II
- Quantum organic chemistry
- Farmacochemistry
- Organic stereochemistry
- Organometallic chemistry
- Organic chemistry of selected elements
DATA
stdClass Object ( [nazev] => Research [seo_title] => Research [seo_desc] => [autor] => [autor_email] => [obsah] =>[poduzel] => Array ( ) [iduzel] => 38653 [canonical_url] => [skupina_www] => Array ( ) [url] => [sablona] => stdClass Object ( [class] => infobox [html] => [css] => [js] => [autonomni] => 0 ) ) ) [sablona] => stdClass Object ( [class] => stranka [html] => [css] => [js] => [autonomni] => 1 ) [api_suffix] => )Electrophilic organic compounds, which enter the human organism from the environment or are formed in vivo as reactive metabolic intermediates, can bind to the nucleophilic sites in proteins and nucleic acids causing damage to these important biomolecules. Binding to the DNA may change genetic information via mutations and may eventually lead to the initiation of carcinogenesis. This process can be studied directly by analysing DNA adducts, or also indirectly, by analysing adducts with blood proteins, i.e., albumin and globin. Both of these adduct types can be used as biomarkers of exposure to electrophilic chemicals as well as biomarkers of the DNA damage, which is connected with carcinogenicity.
We are interested in chemical aspects of the interactions of xenobiotics with important biomolecular targets. Our aim is to develop synthetic methods for preparation of analytical standards to be used for development of new methods of biological monitoring based on determination of DNA and/or protein adducts in body fluids. These standards include derivatives of adenine, guanine and of some amino acids (cysteine, valine, lysine). These are used in research on new methods of biological monitoring. In this field our group collaborates with the group of dr. Jaroslav Mráz of the National Institute of Public Health in Prague.
We also participate in a research on the metabolism of new synthetic drugs, which appear on the illegal street market.
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