Wait a second...
Nepřihlášený uživatel
You are here: VŠCHT PrahaFCHTÚOCH  → Research groups → Perlikova
iduzel: 55928
idvazba: 65127
šablona: stranka
čas: 21.5.2022 21:33:09
verze: 5054
uzivatel:
remoteAPIs:
branch: trunk
Obnovit | RAW

Medicinal chemistry of natural compound inspired scaffolds

Our research is focused on development of migrastatics using natural product inspired scaffolds. We also work on development of antiparasitic compounds, namely with activity against trypanosomatids. In our projects we are combining synthesis of complex molecules and medicinal chemistry.

research

Migrastatics

Metastasis accounts for more than 90% of cancer-related deaths. Despite recent advances in cancer therapies, the majority of patients with advanced-stage solid tumors die as a result of metastatic disease. Migrastatics represent a new concept of drugs with a great potential to improve the outcome of the current cancer treatment strategies by inhibiting metastatic behavior of cancer cells.

Our goal is to use rational design to synthesize new natural compound analogs with antimetastatic activity. We study structure-activity relationships. Antimetastatic activity screening of the new compounds is performed in collaboration with Prof. Jan Brábek group at BIOCEV (Vestec).

Antiparasitic compounds

Trypanosomatids are causative agents of several diseases transmitted by insects: Chagas disease (Trypanosoma cruzi), human african trypanosomiasis known as „sleeping sickness“ (Trypanosoma b. gambiense, Trypanosoma b. rhodesiense) and leischmaniasis (Leischmania sp.). The current treatment of these diseases is complicated. Therefore, we study natural compounds with novel potential mechanism of action and synthesize their analogs for further development as drugs. The new compounds are developed in collaboration with the group of Prof. Vyacheslav Yurchenko (University of Ostrava).

Literature:

  1. Gandalovičová, A.; Rosel, D.; Fernandes, M.; Veselý, P.; Heneberg, P.; Čermák, V.; Petruželka, L.; Kumar, S.; Sanz-Moreno, V.; Brábek, J. Trends Cancer 2017, 3, 391.
Updated: 1.11.2021 15:01, Author: Ondřej Kundrát

Dr. Perlikova group

×

Contact info

Perlíková Pavla, Mgr. et. Mgr., Ph.D.
Building ZB3, room 206
+ 420 220 44 2039
Pavla.Perlikova@vscht.cz 

Formánek Bedřich, Mgr.
Building ZB3, room 206
+ 420 220 44 2039
Bedrich.Formanek@vscht.cz

Lab
Building A, room 262
+ 420 220 44 4276

×


UCT Prague
Technická 5
166 28 Prague 6 – Dejvice
IČO: 60461373 / VAT: CZ60461373

Czech Post certified digital mail code: sp4j9ch

Copyright: UCT Prague 2015
Information provided by the Department of Organic Chemistry. Technical support by the Computing Centre.
switch to desktop version