Medicinal chemistry of natural compound inspired scaffolds
Our research is focused on development of migrastatics using natural product inspired scaffolds. We also work on development of antiparasitic compounds, namely with activity against trypanosomatids. In our projects we are combining synthesis of complex molecules and medicinal chemistry.
Metastasis accounts for more than 90% of cancer-related deaths. Despite recent advances in cancer therapies, the majority of patients with advanced-stage solid tumors die as a result of metastatic disease. Migrastatics represent a new concept of drugs with a great potential to improve the outcome of the current cancer treatment strategies by inhibiting metastatic behavior of cancer cells.
Our goal is to use rational design to synthesize new natural compound analogs with antimetastatic activity. We study structure-activity relationships. Antimetastatic activity screening of the new compounds is performed in collaboration with Prof. Jan Brábek group at BIOCEV (Vestec).
Trypanosomatids are causative agents of several diseases transmitted by insects: Chagas disease (Trypanosoma cruzi), human african trypanosomiasis known as „sleeping sickness“ (Trypanosoma b. gambiense, Trypanosoma b. rhodesiense) and leischmaniasis (Leischmania sp.). The current treatment of these diseases is complicated. Therefore, we study natural compounds with novel potential mechanism of action and synthesize their analogs for further development as drugs. The new compounds are developed in collaboration with the group of Prof. Vyacheslav Yurchenko (University of Ostrava).
- Gandalovičová, A.; Rosel, D.; Fernandes, M.; Veselý, P.; Heneberg, P.; Čermák, V.; Petruželka, L.; Kumar, S.; Sanz-Moreno, V.; Brábek, J. Trends Cancer 2017, 3, 391.