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Selected publications (2005-2019)

Linhart, I.:
Chemická legislativa pohledem laboratorního chemika.
Chem. Listy 2019, 113, 140 – 148.


Mraz, J.; Hanzlikova, I.; Duskova, S.; Dabrowska, L.; Linhart, I.; Hejl, K.:
N-​(2-​Hydroxyethyl)​-​L-​valyl-​L-​leucine in rat urine as a hydrolytic cleavage product of ethylene oxide adduct with globin
Archives of Toxicology 2019 93, 603 – 613 DOI:10.1007/s00204-019-02388-8

Mraz, J.; Hanzlikova, I.; Duskova, S.; Tvrdikova, M.; Chrastecka, H.; Vajtrova, R.; Linhart, I.:
Determination of N-(2-hydroxyethyl)valine in globin of ethylene-exposed workers using total acidic hydrolysis and HPLC-ESI-MS2
Toxicology Letters 2018, 298, 76-80 DOI:10.1016/j.toxlet.2018.06.1212

Zidkova, M.; Linhart, I.; Balikova, M.; Himl, M.; Dvorackova, V.; Lhotkova, E.; Palenicek, T.: 
Identification of three new phase II metabolites of a designer drug methylone formed in rats by N-​demethylation followed by conjugation with dicarboxylic acids
Xenobiotica 2018, 48, 618-625 DOI: 10.1080/00498254.2017.1349964


Linhart, I.; Hanzlikova, I.; Mraz, J.; Duskova, S.:
S-​(3-​Aminobenzanthron-​2-​yl)​cysteine in the globin of rats as a novel type of adduct and possible biomarker of exposure to 3-​nitrobenzanthrone, a potent environmental carcinogen
Archives of Toxicology 2017, 91, 3317-3325 DOI:10.1007/s00204-017-1943-8

Zidkova, M.; Linhart, I.; Balikova, M.; Himl, M.; Vana, L.; Vetyska, M.; Palenicek, T.; Lhotkova, E.; Dusek, M.:
Study on metabolism of 5,6-methylenedioxy-2-aminoindane (MDAI) in rats: identification of urinary metabolites
Xenobiotica 2017, 47, 505-514 DOI:10.1080/00498254.2016.1199919

Mraz, J.; Hanzlikova, I.; Duskova, S.; Dabrowska, L.; Chrastecka, H.; Vajtrova, R.; Linhart, I.:
Biological fate of styrene oxide adducts with globin: Elimination of cleavage products in the rat urine
Toxicology Letters 2016, 261, 26-31 DOI:10.1016/j.toxlet.2016.08.022


Navratil, R.; Tarabek, J.; Linhart, I.; Martinů, T.:
Radical and Nitrenoid Reactivity of 3-Halo-3-phenyldiazirines
Org. Lett. 2016, 18, 3734–3737 DOI:10.1021/acs.orglett.6b01753




J. Mraz, I. Hanzlikova, A. Moulisova, S. Duskova, K. Hejl, A. Bednarova, L. Dabrowska, I. Linhart:
Hydrolytic cleavage products of globin adducts in urine as possible biomarkers of cumulative dose: Proof of concept using styrene oxide as a model adduct-forming compound
Chemical Research in Toxicology 29, 676-686 (2016)

I. Linhart, M. Himl, M. Zidkova, M. Balikova, E. Lhotakova, T. Palenicek: 
Metabolic profile of mephedrone: Identification of normephedrone conjugates with dicarboxylic acids as a new type of xenobiotic phase II metabolites
Toxicology Letters 240, 114-121 (2016) 


A. Kralík, I. Linhart, L. Váňa, A. Moulisová:
Identification of new DNA adducts of phenylnitrenium
Chemical Research in Toxicology 28, 1317-1325 (2015)

 

A. Moulisová, I. Linhart:
Preparation of cysteine adducts by regioselective ring-opening reactions of phenyloxirane
Heterocyclic Commun. 21, 61-65 (2015)

 
L. Váňa, L. Vrzal, H. Dvořáková, M. Himl a I. Linhart:
Direct arylation of adenine by fluoro- and chloronitrobenzenes. Effect of microwaves.

Synth. Commun. 44, 788-799 (2014)

  

P. Mikeš, V. Šístek, J. Krouželka, A. Králík, E. Frantík, J. Mráz a I. Linhart:

3-(3,4-Dihydroxyphenyl)adenine, a urinary DNA adduct formed in mice exposed to high concentrations of benzene.

Appl. Toxicol. 33, 516-520 (2013)

 

I. Linhart:

Toxikologie. Interakce škodlivých látek s živými organismy, jejich mechanismy, projevy a důsledky.

ISBN: 978-80-7080-806-1, VŠCHT Praha, 2012

 

K. Míčová, I. Linhart:

Reactions of benzene oxide, a reactive metabolite of benzene, with model nucleophiles and DNA.

Xenobiotica 42, 1028-1037 (2012)

I. Linhart, J. Mráz, I. Hanzlíková, A. Šilhánková, E. Frantík, M. Himl:

Carcinogenic 3-nitro-benzanthrone but not 2-nitrobenzanthrone is metabolised to an unusual mercapturic acid in rats.

Toxicol. Lett. 208, 246-253 (2012)

 

I. Linhart, J. Mráz, L. Danbrowská, M. Mališ, J. Krouželka, M. Kořínek:

Viniylmercapturic acids in human urine as biomarkers of styrene ring oxidation.

Toxicol. Lett. 213, 260-265 (2012)

I. Linhart, P. Mikeš, A. Králík, J. Mráz, E. Frantík:

Metabolism of N2-(4-hydroxyphenyl)guanine, a DNA adduct formed from p-benzoquinone, in rat.

Toxicol. Lett. 205, 273-278 (2011)

I. Linhart, P. Mikeš, E. Frantík, J Mráz:

DNA Adducts Formed from p-Benzoquinone, an Electrophilic Metabolite of Benzene, Are Extensively Metabolized in Vivo.

Chem. Res. Toxicol. 24, 383-391 (2011)

P. Mikeš, M. Kořínek, I. Linhart, J. Krouželka, L. Dabrowská, V. Stránský, J. Mráz:

Urinary N3 adenine DNA adducts in humans occupationally exposed to styrene.

Toxicol. Lett. 197, 183-187 (2010)

 

I. Linhart, J. Mráz, J. Scharff, J. Krouželka, S. Dušková, H. Nohová, L. Vodičková:
New Urinary Metabolites Formed from Ring-Oxidized Metabolic Intermediates of Styrene
Chem. Res. Toxicol., 23, 251-257 (2010)

 

J. Krouželka, I. Linhart:
Copper-mediated N-arylation in the synthesis of aryladenines
Heterocycles, 78, 1205-1226 (2009)

 

P. Mikeš, M. Kořínek, I. Linhart, J. Krouželka, E. Frantík, L. Vodičková, N. Neufussová:
Excretion of urinary N7 guanine and N3 adenine DNA adducts in mice after inhalation of styrene
Toxicol. Lett., 184, 33-37 (2009)

 

J. Krouželka, I. Linhart, T. Tobrman:
Synthesis of 3-(2-hydroxy-1-phenyl)- and 3-(2-hydroxy-2-phenylethyl)adenine, DNA adducts derived from styrene
J. Heterocycl. Chem., 45, 789-795 (2008)

 

Jagr, M., Mráz, J., Linhart, I., Stránský, V., Pospíšil, M.
Synthesis and characterization of styrene oxide adducts with cysteine, histidine and lysine in human globin
Chem. Res. Toxicol., 20, 1442-1452 (2007)

 

Gut, I., Ojima, I., Vaclavikova, R., Simek, P., Horsky, S., Linhart, I., Soucek, P., Kondrova, E., Kuznetsova, L.V.
Xenobiotica, 36, 772-792 (2006)

 

Vodicka, P.; Linhart, I.; Novak, J.; Koskinen, M.; Vodickova, L.; Hemminki, K.:
7-Alkylguanine adduct levels in urine, lungs and liver of mice exposed to styrene
Tox. Appl. Pharmacol., 210, 1-8 (2006)

 

Novák, J.; Hasník, Z.; Linhart, I.:
Syntheses of O6-alkyl- and arylguanine derivatives, nucleobase adducts derived from styrene 7,8- and 3,4-oxide
Eur. J. Org. Chem., 507-515 (2006)

  

Dostalek, M.; Pistovcakova, J.; Jurica, J.; Tomandl, J.; Linhart, I.; Sulcova, A.; Hadasova, E.:
Effect of St. John´s wort (Hypericum perforatum) on cytochrome P-450 activity in perfused rat liver
Life Sci. 78, 239-244 (2005)

Updated: 12.7.2019 18:28, Author: Ondřej Kundrát


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