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PhD topics for academic year 2018/2019

Organic Chemistry

Study Programme: Chemistry

Biomimetic redox systems for photoorganocatalysis

Cibulka Radek, prof. Ing. Ph.D. ( cib...@vscht.cz)
Investigation of biochemical processes in enzymes not only brings knowledge about biological processes but, moreover, it is inexhaustible inspiration to design new artificial systems with practical applications, e.g. in medicinal diagnostic, organic synthesis or in modern analytical chemistry. The work will be focused on study of flavin cofactors and their role in redox and photochemical processes. The study will be performed both on models prepared within the work and using enzymes. The results will be used to design new green catalytical systems for modern organic synthesis. The work is focused on synthetic organic chemistry combined with photofyzical measurements of flavin systems. Research will be performed in cooperation with universities abroad.

Calixarenes with mixed bridges

Lhoták Pavel, prof. Ing. CSc. ( lho...@vscht.cz)
The presence of sulfur bridges in thiacalixarenes invokes a dramatic change not only in the complexation behaviour and conformational preferences, but also in the basic chemistry of such calixarenes. Consequently, it would be very interesting to know the chemistry and conformational behaviour of such calixarene systems possessing mixed bridges (such as-S- , -CH2-, -Se-, -O-, -NR-, or -CH2-O-CH2-, within one molecule. These mixed systems (e.g.: S/CH2) could retain the properties of both parent macrocycles which could find many applications in supramolecular chemistry, including the design of novel receptor types.

Cooperative flavin systems for organic photoredox catalysis

Cibulka Radek, prof. Ing. Ph.D. ( cib...@vscht.cz)
Flavins are redox-active compounds which effectively enter excited state upon irradiation with visible light. Importantly, they are photoactive both in oxidative and reductive form. Thus, in excited state, flavins are strong oxidizing or reducing agents which allow their participation both in oxidative and reductive part of the catalytic cycle. The aim of the work is to design catalytic systems with two cooperating flavin derivatives allowing new chemical transformations under mild conditions, for example C-H derivatization or C-C coupling. Work is focused on synthetic organic chemistry, nevertheless characterization of flavin catalysts by electrochemical or spectroscopic methods will be performed as well. Research will be performed in cooperation with universities abroad.

Design and synthesis of multifunctional liquid crystals

Kohout Michal, doc. Ing. Ph.D. ( mic...@vscht.cz)
The aim of work is design and synthesis of novel liquid crystalline materials, whose mesomorphic behaviour can be directed by various external stimuli, namely electric and magnetic field as well as light of a specific wavelength. Thus, series of chiral and achiral materials bearing photosensitive unit (azo group, spiropyran, etc.), radical (e.g. TEMPO) will be synthesized; compounds can also be connected to magnetic nanoparticles. Mesomorphic behaviour and physical properties of prepared materials will be studied in cooperation with national as well as foreign institutions. The work is a part of grant projects which are currently being solved in our laboratory.

Design, synthesis and evaluation of separation properties of novel chiral ion-exchangers

Kohout Michal, doc. Ing. Ph.D. ( mic...@vscht.cz)
The aim of the work is to develop a straightforward synthetic pathway towards novel chiral ion exchangers and utilize such materials as chiral stationary phases in HPLC and SFC. The chiral stationary phases will be based on various ionisable organic molecules immobilized onto a solid support. The resulting ion exchangers will be evaluated using various ionisable racemic compounds (pharmaceuticals, new synthetic drugs, etc.). Based on the achieved results, the structure of the selector will be optimized to provide high level of applicability in chiral separations. The work is a part of a grant project, which is currently being solved in our laboratory.

Flavin-based photocatalytic systems for C-H activations

Cibulka Radek, prof. Ing. Ph.D. ( cib...@vscht.cz)
Flavins are redox-active compounds which effectively enter excited state upon irradiation with visible light. Thus flavins become strong oxidizing agents which are able to oxidize chemoselectively activated C-H bonds. This property will be studied with the aim to find method for chemoselective C-H activation and subsequent derivatization of aromatic and aliphatic compounds under mild conditions. The methodology should allow direct functionalization of hydrocarbons and will be applied in the synthesis of biologically active compounds. Work belongs to the area of photoredox catalysis and it combines modern synthetic organic chemistry, photochemistry and investigation of spectroscopic and electrochemical properties of molecules. Design of flavin catalysts will be performed based on structure-activity relationship and using modern computational methods. Research will be performed in cooperation with universities abroad.

Fullerene complexation using higher calixarenes

Lhoták Pavel, prof. Ing. CSc. ( lho...@vscht.cz)
The aim of this work is the design and synthesis of higher calixarenes (calix[5]- to calix[8]arenes) that could be applied as receptors for the fullerene recognition. The aim of this work is to achieve selective complexation of C60 or C70 using suitably chemically modified calixarene skeletons and concave/convex principle of the interactions. Novel compounds will be used as receptors for the complexation of fullerenes and as the building blocks for construction of supramolecular self-assembly systems.

Organosilica materials for heterogeneous catalysis of enantioselective reactions

Hodačová Jana, doc. Dr. Ing. ( Jan...@vscht.cz)
The project deals with a development of novel heterogeneous catalysts of enantioselective reactions based on the hybrid organic-inorganic materials. Appropriate enantiomerically pure organic compounds will be synthesized, and then they will be transformed to the so called bridged bis(trialkoxysilanes). The bridged bis(trialkoxysilanes) will be subjected to a sol-gel process under various experimental conditions. The obtained solid organosilica materials will be fully characterised and their abililies to catalyse selected enantioselective reactions will be studied. Based on the obtained results, the structure of the enantiomerically pure organic fragment as well as the conditions of the sol-gel process will be optimized. The project will be solved in collaboration with the Technical University in Liberec and is financially supported by the Czech Science Foundation (Reg. No. 18-09824S).

The preparation of tetrasubstituted alkenes bearing pyrene cores

Tobrman Tomáš, doc. Ing. Ph.D. ( tom...@vscht.cz)
The aim of the thesis is development of novel protocols for the preparation of π-conjugated molecules containing at least two pyrene cores. Prepared substances will be used for the preparation of OFETs.
Updated: 20.2.2017 10:45, Author: Miroslav Šimek


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