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166 28 Prague 6 – Dejvice
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Copyright: UCT Prague 2015
Information provided by the Department of Organic Chemistry. Technical support by the Computing Centre.
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All publications of our authors (since 2015): here
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| k Phonebook of the Department | |||
Professors: |
|||
|
Prof. Radek Cibulka e +420 22044 4182 d A 278c |
Head of Department | www | ResearcherID |
|
Prof. Pavel Lhoták e +420 22044 5055 d A 249 |
www | ||
|
Prof. Jaroslav Kvíčala e +420 22044 4240 d A 278d |
www | ||
|
Prof. Jiří Svoboda e +420 22044 3688 d A 278e |
www | ||
Associate Professors: |
|||
|
Assoc. Prof. Jan Budka e +420 22044 4284 d A 251 |
DOC web editor | www | |
|
Assoc. Prof. Jana Hodačová e +420 22044 4173 d A 270 |
www | ||
|
Assoc. Prof. Michal Kohout e +420 22044 5012 d A 258 |
www | ||
|
Assoc. Prof. Igor Linhart e +420 22044 4165 d A 266 |
www | ||
|
Assoc. Prof. Tomáš Tobrman e +420 22044 4245 d A 271 |
RIT | www | |
Assistant Professors: |
|||
|
Dr. Michal Himl e +420 22044 4165 d A 266 |
www | ||
|
Dr. Roman Holakovský e +420 22044 4279 d A 255 |
www | ||
|
Dr. Petr Kovaříček e +420 22044 2040 d B3 207 |
www | ||
|
Dr. Václav Kozmík e +420 22044 4118 d A 308 |
www | ||
|
Dr. Martin Krupička e +420 220 444 173 |
www | ||
|
Dr. Ondřej Kundrát e +420 22044 4280 d A 253 |
www | ResearcherID | |
|
Dr. Petra Ménová e +420 22044 3686 d A 268 |
www | ||
|
Dr. Pavla Perlíková e +420 22044 2039 d B3 206 |
www | ||
|
Dr. Markéta Rybáčková e +420 22044 4242 d A 259 |
Secretary of Department |
www | |
|
Dr. Eva Svobodová e +420 22044 4249 d A 260 |
www | ||
Technicians: |
|||
|
Květa Bártová e +420 22044 3686 d A 268 |
|||
|
Ivana Bocková, MSc. e +420 22044 4280 d A 250 |
|||
| Michaela Kadlecová
e +420 22044 4276 d A 262 b Michaela.Kadlecova@vscht.cz |
|||
|
Martina Kovandová e +420 22044 4279 d A 255 |
|||
|
Vladimír Kuneš e +420 22044 4277 d A L06 |
|||
|
Jana Netušilová e +420 22044 4164 d A 278a |
Administrative Support of Department | ||
|
Markéta Slabochová, MSc. e +420 22044 4059 d A 308 |
Economist of Department | ||
|
Helena Štenglová e +420 22044 4278 d A 257 |
|||
|
Ing. David Tetour e +420 22044 4173 d A270 |
|||
|
Marta Tokárová e +420 220 444 245 d A 271 |
|||
Essential Information for Current Students
Bachelor Students
Master Students
PhD Students
Lectures delivered by members of the Department
- Toxicology and ecology
- Organic chemistry I, II and III
- Structural analysis
- Reactivity of organic compounds
- Molecular design
- Organic synthesis I and II
- Quantum organic chemistry
- Farmacochemistry
- Organic stereochemistry
- Organometallic chemistry
- Organic chemistry of selected elements
DATA
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[obsah] => Medicinal chemistry of natural compound inspired scaffolds
The research group led by Mgr. et Mgr. Pavla Perlíková, Ph.D.
We are looking for a postdoctoral researcher. More information here.
Our research is focused on development of migrastatics using natural product-inspired scaffolds. We also work on development of antiparasitic compounds, namely with activity against trypanosomatids. In our projects, we are combining synthesis of complex molecules and medicinal chemistry.
More details about the projects can be found in the Research section.
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[obsah] => Publications
Formánek, B.; Dupommier, D.; Volfová, T.; Rimpelová, S.; Škarková, A.; Herciková, J.; Rösel, D.; Brábek, J.; Perlíková, P.: Synthesis and migrastatic activity of cytochalasin analogues lacking a macrocyclic moiety. RSC Med. Chem. 2024, 15, 322-343. DOI: 10.1039/D3MD00535F
You can find older publications HERE.
Pavla Perlíková
Building ZB3, room 206
+ 420 220 44 2039
Pavla.Perlikova@vscht.cz
Lab
Building A, room 262
+ 420 220 44 4276
Open positions
We are looking for a postdoctoral researcher for our project: Development of actin polymerization inhibitors as potential migrastatics. The project is funded by the Czech Science Foundation. Expected start: January 2025. Interested candidates should contact the group leader by e-mail.
Pavla Perlíková
Building ZB3, room 206
+ 420 220 44 2039
Pavla.Perlikova@vscht.cz
Lab
Building A, room 262
+ 420 220 44 4276
Pavla Perlíková
Building ZB3, room 206
+ 420 220 44 2039
Pavla.Perlikova@vscht.cz
Lab
Building A, room 262
+ 420 220 44 4276
Research topics of the group
Migrastatics
Metastasis accounts for more than 90% of cancer-related deaths. Despite recent advances in cancer therapies, the majority of patients with advanced-stage solid tumors die as a result of metastatic disease. Migrastatics represent a new concept of drugs with a great potential to improve the outcome of the current cancer treatment strategies by inhibiting metastatic behavior of cancer cells.
Our goal is to use rational design to synthesize new natural compound analogs with antimetastatic activity. We study structure-activity relationships. Our protein target is actin and actin polymerization regulators, such as the Arp2/3 complex. Antimetastatic activity screening of the new compounds is performed in collaboration with Prof. Jan Brábek group at BIOCEV (Vestec, Czechia).
Projects:
2023-2027: Development of actin polymerization inhibitors as potential migrastatics (GAČR)
2021-2022: Development of actin-targeting compounds with anti-metastatic effect (Dagmar Procházková Fund)
Transcription factor inhibitors
The regulation of cell signaling is one of the most common mechanisms of action for drugs. It is possible to affect cell receptors as well as signal transduction within the cell. Gene expression can also be affected indirectly. However, direct regulation of protein expression by targeting transcription factors is challenging. So far, only a small fraction of them, the so-called nuclear receptors, have been exploited because most transcription factors do not contain binding sites for small molecules.
In our group, we are working on the rational design of inhibitors of other transcription factors involved in metabolic disorders such as diabetes, obesity and infertility. In this project we collaborate within the VSČHT with the groups of prof. Andrea Brancale and Prof. Daniel Svozil.
Projects:
2024-2028: NETPHARM: New technologies for translational research in pharmaceutical sciences (OP JAK)
Antiparasitic compounds
Trypanosomatids are causative agents of several diseases transmitted by insects: Chagas disease (Trypanosoma cruzi), human african trypanosomiasis known as „sleeping sickness“ (Trypanosoma b. gambiense, Trypanosoma b. rhodesiense) and leishmaniasis (Leishmania sp.). The current treatment of these diseases is complicated. Therefore, we study natural compounds, elucidate their mechanism of action and synthesize their analogs for further development as potential drugs. New compounds are developed in collaboration with the group of Prof. Vyacheslav Yurchenko (University of Ostrava).
Pavla Perlíková
Building ZB3, room 206
+ 420 220 44 2039
Pavla.Perlikova@vscht.cz
Lab
Building A, room 262
+ 420 220 44 4276
People in research group
Group leader:
Postdoc researcher:
- Dorian Dupommier
- Wim Dehaen
PhD students:
- Žaneta Javorská
- Michal Trojan
- Katarzyna Kwiecińska
Students:
- Daniel Kozový
- Jiří Ferenczei
- Veronika Švecová
- Matěj Říha
- Artem Lobanov
Laboratory staff:
Michaela Kadlecová
Alumni:
Bedřich Formánek
Vilém Blahout
Tereza Kubátová
Mgr. et Mgr. Pavla Perlíková, Ph.D.
e-mail: perlikop@vscht.cz
phone: +420 220442039
Scientific CV:
2003-2006 undergraduate study, Charles University in Prague - Faculty of Science, Bc. S. degree - specialization organic chemistry (supervisor Dr. Jan Šarek)
2004-2007 undergraduate study, Charles University in Prague - Faculty of Science, Bc. S. degree - specialization molecular biology and biochemistry (supervisor Associate Prof. Marián Hajdúch)
2006-2008 undergraduate study, Charles University in Prague - Faculty of Science, M. S. degree - specialization organic chemistry (supervisor RNDr. Jan Šarek, Ph.D.)
2007-2009 undergraduate study, Charles University in Prague - Faculty of Science, M. S. degree - specialization cell biology (supervisor Associate Prof. Marián Hajdúch)
2008-2012 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)
2012-2013 postdoctoral position, University of Southern Denmark (supervisor prof. Jesper Wengel)
2013-2020 postdoctoral position, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)
since 2021 assistant professor, University of Chemistry and Technology Prague
Awards:
2008 Zentiva award for the best diploma thesis
2011 Best oral presentation, XV Symposium on Chemistry of Nucleic Acid Components, Český Krumlov
2012 Prix Sanofi Pharmacie (3rd position)
2017 Otto Wichterle Award
2019 Alfred Bader Prize for Bioorganic and Bioinorganic Chemistry (CAB II 2019)
Publications HERE
Pavla Perlíková
Building ZB3, room 206
+ 420 220 44 2039
Pavla.Perlikova@vscht.cz
Lab
Building A, room 262
+ 420 220 44 4276